FluoroFinder

	Supplier
	Catalog #:	NB100-2788AF405 (View supplier product page)
	Size	100 μl
	Price	$379.00
	Antigen	p53
	Clone	Pab 1104
	Host	Mouse
	Isotype	IgM
	Conjugate	Alexa Fluor 405
	Target Species	Human
	Applications	IHC

	p53	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
	Alexa Fluor 405	Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

p53 Monoclonal / Alexa Fluor 405 / Pab 1104