Myelin Protein Zero Monoclonal / Alexa Fluor 405 / R5.21C
Myelin Protein Zero Monoclonal / Alexa Fluor 405 / R5.21C
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NBP2-54360AF405 (View supplier product page) | |
| Size | 100 μl | |
| Price | $399.00 | |
| Antigen | Myelin Protein Zero | |
| Clone | R5.21C | |
| Host | Rat | |
| Isotype | IgG2a | |
| Conjugate | Alexa Fluor 405 | |
| Target Species | Mouse, Rat | |
| Applications | WB, FC, ICC/IF, IHC-Fr |
About Myelin Protein Zero and Alexa Fluor 405
| Myelin Protein Zero | This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015] | |
|---|---|---|
| Alexa Fluor 405 | Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications. |
Citations
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