FluoroFinder

	Supplier
	Catalog #:	NBP1-77272 (View supplier product page)
	Size	100 μg
	Price	$329.00
	Antigen	Aph-1
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human, Mouse, Rat
	Applications	WB, ELISA, IHC, IHC-P

	Aph-1	This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]

		Western Blot: APH1A Antibody [NBP1-77272] - Human brain tissue lysate with APH1a antibody at (A) 0.5 and (B) 1 ug/ml.
		Western Blot: APH1A Antibody [NBP1-77272] - Analysis of APH1 in RAW264.7 cell lysate with APH1 antibody at (A) 1 and (B) 2 ug/mL.
		Immunohistochemistry-Paraffin: APH1A Antibody [NBP1-77272] - Human brain tissue with APH1a antibody at 5 ug/ml.