FluoroFinder

	Supplier
	Catalog #:	NBP2-12082JF646 (View supplier product page)
	Size	100 μl
	Price	$429.00
	Antigen	Cathepsin L
	Clone	RM0166-5G14
	Host	Rat
	Isotype	IgG2
	Conjugate	Janelia Fluor 646
	Target Species	Mouse
	Applications	IHC, IHC-P

	Cathepsin L	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]
	Janelia Fluor 646	Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.

	Additional Sources

Cathepsin L Monoclonal / Janelia Fluor 646 / RM0166-5G14