FluoroFinder

	Supplier
	Catalog #:	NBP2-50429JF549 (View supplier product page)
	Size	100 μl
	Price	$329.00
	Antigen	KMT2A/MLL
	Clone	HRX107
	Host	Mouse
	Isotype	IgM
	Conjugate	Janelia Fluor 549
	Target Species	Human
	Applications	IHC, ICC/IF

	KMT2A/MLL	This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
	Janelia Fluor 549	Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.

	Additional Sources

KMT2A/MLL Monoclonal / Janelia Fluor 549 / HRX107