FluoroFinder

	Supplier
	Catalog #:	NBP2-23545IR (View supplier product page)
	Size	100 μl
	Price	$329.00
	Antigen	Complement C5
	Clone	12F3
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	DyLight 755
	Target Species	Human
	Applications	WB, ELISA
	Description	Optimal dilution of this antibody should be experimentally determined.

	Complement C5	This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
	DyLight 755	DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.

	Additional Sources

Complement C5 Monoclonal / DyLight 755 / 12F3