FluoroFinder

	Supplier
	Catalog #:	NBP2-37397UV (View supplier product page)
	Size	100 μl
	Price	$399.00
	Antigen	Aldehyde Dehydrogenase 2
	Clone	4G6A3
	Host	Mouse
	Isotype	IgG1
	Conjugate	DyLight 350
	Target Species	Human, Mouse, Rat
	Applications	WB, ELISA, FC, ICC/IF

	Aldehyde Dehydrogenase 2	This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
	DyLight 350	DyLight™ 350 has an excitation peak of 353 nm and an emission peak of 432 nm. It is spectrally similar to Alexa Fluor™ 350, iFluor® 350, AMCA, and Thioflavin T. DyLight™ 350 is most commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

Aldehyde Dehydrogenase 2 / DyLight 350 / 4G6A3