FluoroFinder

	Supplier
	Catalog #:	NBP2-37469C (View supplier product page)
	Size	100 μl
	Price	$399.00
	Antigen	Vav-1
	Clone	200000000000.0
	Host	Mouse
	Isotype	IgG1
	Conjugate	DyLight 650
	Target Species	Human
	Applications	WB, ELISA, FC

	Vav-1	This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
	DyLight 650	DyLight™ 650 is a red-emitting fluorophore that excited by the 640 nm laser and collected using a 670/30 nm bandpass filter. DyLight™ 650 has an excitation peak at 652 nm and an emission peak at 672 nm, and is spectrally similar to Alexa Fluor™ 647 and Cy5. DyLight™ 650 is most commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

Vav-1 / DyLight 650 / 200000000000.0