FluoroFinder

	Supplier
	Catalog #:	NBP2-52462AF405 (View supplier product page)
	Size	100 μl
	Price	$429.00
	Antigen	ErbB4
	Clone	5G6B4
	Host	Mouse
	Isotype	IgG1
	Conjugate	Alexa Fluor 405
	Target Species	Human
	Applications	WB, ELISA, FC

	ErbB4	This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
	Alexa Fluor 405	Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

ErbB4 / Alexa Fluor 405 / 5G6B4