Syntrophin alpha 1 / DyLight 405LS / 1E1
Syntrophin alpha 1 / DyLight 405LS / 1E1
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NBP2-22587V3 (View supplier product page) | |
| Size | 100 μl | |
| Price | $369.00 | |
| Antigen | Syntrophin alpha 1 | |
| Clone | 1E1 | |
| Host | Mouse | |
| Isotype | IgG2b κ | |
| Conjugate | DyLight 405LS | |
| Target Species | Human | |
| Applications | WB, ELISA | |
| Description | Protein A purified |
About Syntrophin alpha 1 and DyLight 405LS
| Syntrophin alpha 1 | Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013] |
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Citations
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