Elongin B / DyLight 405LS / 10C4
Elongin B / DyLight 405LS / 10C4
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NB100-78489V3 (View supplier product page) | |
| Size | 100 μl | |
| Price | $369.00 | |
| Antigen | Elongin B | |
| Clone | 10C4 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | DyLight 405LS | |
| Target Species | Human | |
| Applications | WB | |
| Description | Protein G purified |
About Elongin B and DyLight 405LS
| Elongin B | This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008] |
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Citations
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