FluoroFinder

	Supplier
	Catalog #:	NBP1-45148FR (View supplier product page)
	Size	250 μl
	Price	$379.00
	Antigen	Coagulation Factor VII
	Clone	RFF-VII/2
	Host	Mouse
	Isotype	IgG1
	Conjugate	DyLight 680
	Target Species	Human
	Applications	WB, ELISA

	Coagulation Factor VII	This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
	DyLight 680	DyLight™ 680 has an excitation peak at 692 nm and an emission peak at 712 nm, and is spectrally similar to Alexa Fluor™ 680 and Cy5.5. DyLight™ 680 is most commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

Coagulation Factor VII / DyLight 680 / RFF-VII/2