CD40 / DyLight 680 / 39530
CD40 / DyLight 680 / 39530
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NB100-64736FR (View supplier product page) | |
| Size | 125 μl | |
| Price | $379.00 | |
| Antigen | CD40 | |
| Clone | 39530 | |
| Host | Rat | |
| Isotype | IgG2a | |
| Conjugate | DyLight 680 | |
| Target Species | Mouse | |
| Applications | ELISA, FC, IHC-Fr |
About CD40 and DyLight 680
| CD40 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] | |
|---|---|---|
| DyLight 680 | DyLight™ 680 has an excitation peak at 692 nm and an emission peak at 712 nm, and is spectrally similar to Alexa Fluor™ 680 and Cy5.5. DyLight™ 680 is most commonly used in flow cytometery and fluorescence microscopy applications. |
Citations
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