CD25 / Alexa Fluor 700 / RM134L
CD25 / Alexa Fluor 700 / RM134L
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NBP1-43277AF700 (View supplier product page) | |
| Size | 100 μl | |
| Price | $369.00 | |
| Antigen | CD25 | |
| Clone | RM134L | |
| Host | Rat | |
| Isotype | IgG2b κ | |
| Conjugate | Alexa Fluor 700 | |
| Target Species | Mouse | |
| Applications | FC, IHC-Fr | |
| Description | Protein A or G purified |
About CD25 and Alexa Fluor 700
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| Alexa Fluor 700 | Alexa Fluor™ 700 (AF700, Alexa 700) has an excitation peak at 702 nm and an emission peak at 723 nm, and is spectrally similar to iFluor® 680 (ATT Bioquest) and iFluor® 700 (ATT Bioquest). Alexa 700 is commonly used in Flow Cytometry and is similar in size, brightness and application to iFluor® 700 and Vio® R720. |
Citations
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