Ghrelin / DyLight 755 / Ghr5
Ghrelin / DyLight 755 / Ghr5
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NB110-11813IR (View supplier product page) | |
| Size | 100 μl | |
| Price | $299.00 | |
| Antigen | Ghrelin | |
| Clone | Ghr5 | |
| Host | Mouse | |
| Isotype | IgG3 | |
| Conjugate | DyLight 755 | |
| Target Species | Human | |
| Applications | ELISA | |
| Description | Optimal dilution of this antibody should be experimentally determined. |
About Ghrelin and DyLight 755
| Ghrelin | This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014] | |
|---|---|---|
| DyLight 755 | DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy. |
Citations
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