PXR / DyLight 405LS / V11P4G11/E7
PXR / DyLight 405LS / V11P4G11/E7
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NBP2-50519V3 (View supplier product page) | |
| Size | 100 μl | |
| Price | $329.00 | |
| Antigen | PXR | |
| Clone | V11P4G11/E7 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | DyLight 405LS | |
| Target Species | Zebrafish | |
| Applications | WB, ELISA | |
| Description | Protein G purified |
About PXR and DyLight 405LS
| PXR | This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] |
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Citations
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