Androgen Receptor / PerCP / AR441 + DHTR/882
Androgen Receptor / PerCP / AR441 + DHTR/882
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NBP2-44789PCP (View supplier product page) | |
| Size | 100 μl | |
| Price | $399.00 | |
| Antigen | Androgen Receptor | |
| Clone | AR441 + DHTR/882 | |
| Host | Mouse | |
| Isotype | IgG | |
| Conjugate | PerCP | |
| Target Species | Human, Mouse (Negative) | |
| Applications | IHC-P | |
| Description | Protein A or G purified |
About Androgen Receptor and PerCP
| Androgen Receptor | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017] | |
|---|---|---|
| PerCP | Peridinin-Chlorophyll-Protein (PerCP) is a red-emitting fluorescent protein isolated from algae that can be excited by the 488 nm blue laser and captured with a 670/30 nm bandpass filter. PerCP exhibits a large Stokes' Shift, with an excitation peak at 482 nm and an emission peak at 675 nm. PerCP is was historically used in flow cytometry, however it is highly susceptible to photobleaching and has poor stability. Alternatives like BB700, NovaFluor Blue 690 or PerCP-eFluor™ 710 are preferred. PerCP is a generic dye that has no sole manufacturer. |
Citations
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