CD124 / APC / 25463
CD124 / APC / 25463
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | FAB230A (View supplier product page) | |
| Size | 100 Tests | |
| Price | ||
| Antigen | CD124 | |
| Clone | 25463 | |
| Host | Mouse | |
| Isotype | IgG2a | |
| Conjugate | APC | |
| Target Species | Human | |
| Applications | FC | |
| Description | Human IL-4 R alpha Allophycocyanin MAb (Clone 25463) |
About CD124 and APC
| CD124 | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Citations
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