IL-8 / NL 557 / 6217
IL-8 / NL 557 / 6217
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NL208R (View supplier product page) | |
| Size | 500 μl | |
| Price | $355.00 | |
| Antigen | IL-8 | |
| Clone | 6217 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | NL 557 | |
| Target Species | Human | |
| Applications | ICC | |
| Description | Human CXCL8/IL-8 NL557 MAb (Clone 6217) - |
About IL-8 and NL 557
| IL-8 | The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020] | |
|---|---|---|
| NL 557 | NL 557 from Bio-Techne is a fluorophore with an excitation peak at 557 nm and an emission peak at 574 nm. It can be used in fluorescence microscopy. |
Citations
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