DISABLED HOMOLOG 2 / Unconjugated /
DISABLED HOMOLOG 2 / Unconjugated /
Product Details
| Supplier | ProSci | |
|---|---|---|
| Catalog #: | 60-666-400UL (View supplier product page) | |
| Size | 400 μl | |
| Price | $482.00 | |
| Antigen | DISABLED HOMOLOG 2 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | Ig | |
| Conjugate | Unconjugated | |
| Target Species | Mouse | |
| Applications | WB | |
| Description | Mouse Dab2 Antibody |
About DISABLED HOMOLOG 2 and Purified
| DISABLED HOMOLOG 2 | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
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Citations
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