CTIF / Unconjugated /
CTIF / Unconjugated /
Product Details
| Supplier | ProSci | |
|---|---|---|
| Catalog #: | 25-647-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $482.00 | |
| Antigen | CTIF | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB | |
| Description | KIAA0427 Antibody |
About CTIF and Purified
| CTIF | CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009] |
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Citations
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