FluoroFinder

	Supplier	ProSci
	Catalog #:	99-021-0.1MG (View supplier product page)
	Size	100 μg
	Price	$422.00
	Antigen	CD117
	Clone	2B8
	Host	Rat
	Isotype	IgG2b
	Conjugate	APC-Cy5.5
	Target Species	Mouse
	Applications	FC
	Description	CD117 Antibody [2B8] (APC-Cy5.5)

	CD117	This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
	APC-Cy5.5	APC-Cy5.5 has an excitation peak at 651 nm and 695 nm and is useful in flow cytometry. However, alternatives like APC-Alexa 680 and APC-R700 have proved better in many stability tests.

	Additional Sources

CD117 / APC-Cy5.5 / 2B8