FluoroFinder

	Supplier
	Catalog #:	NB100-1899AF405 (View supplier product page)
	Size	100 Tests
	Price	$329.00
	Antigen	Von Hippel Lindau
	Clone	Polyclonal
	Host	Rabbit
	Isotype	IgG
	Conjugate	Alexa Fluor 405
	Target Species	Human
	Applications	WB, IHC-P
	Description	Immunogen affinity purified

	Von Hippel Lindau	Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
	Alexa Fluor 405	Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

Von Hippel Lindau / Alexa Fluor 405 / Polyclonal