FluoroFinder

	Supplier
	Catalog #:	NB100-56514AF405 (View supplier product page)
	Size	100 Tests
	Price	$329.00
	Antigen	Dnmt3b
	Clone	52A1018
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	Alexa Fluor 405
	Target Species	Human, Mouse
	Applications	WB, ChIP, IHC-P, ICC, IF
	Description	Protein G purified

	Dnmt3b	CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
	Alexa Fluor 405	Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

Dnmt3b / Alexa Fluor 405 / 52A1018