PKA 2 beta / Alexa Fluor 647 / RS17
PKA 2 beta / Alexa Fluor 647 / RS17
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NB100-73069AF647 (View supplier product page) | |
| Size | 200 μl | |
| Price | $279.00 | |
| Antigen | PKA 2 beta | |
| Clone | RS17 | |
| Host | Mouse | |
| Isotype | IgG2a | |
| Conjugate | Alexa Fluor 647 | |
| Target Species | Bovine, Human, Porcine | |
| Applications | ICC/IF, ELISA |
About PKA 2 beta and Alexa Fluor 647
| PKA 2 beta | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| Alexa Fluor 647 | Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye. |
Citations
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