RNF111 / Alexa Fluor 488 / 1C4
RNF111 / Alexa Fluor 488 / 1C4
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | H00054778-M05AF488 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $429.00 | |
| Antigen | RNF111 | |
| Clone | 1C4 | |
| Host | Mouse | |
| Isotype | IgG2a κ | |
| Conjugate | Alexa Fluor 488 | |
| Target Species | Human | |
| Applications | ICC, WB | |
| Description | IgG purified - - |
About RNF111 and Alexa Fluor 488
| RNF111 | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] | |
|---|---|---|
| Alexa Fluor 488 | Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A. |
Citations
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