FluoroFinder

	Supplier
	Catalog #:	H00007536-M01AF488 (View supplier product page)
	Size	100 Tests
	Price	$429.00
	Antigen	Splicing Factor 1
	Clone	2E12
	Host	Mouse
	Isotype	IgG2a κ
	Conjugate	Alexa Fluor 488
	Target Species	Human
	Applications	IF, WB, IHC, IP, ICC
	Description	IgG purified - -

	Splicing Factor 1	This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
	Alexa Fluor 488	Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.

	Additional Sources

Splicing Factor 1 / Alexa Fluor 488 / 2E12