FluoroFinder

	Supplier
	Catalog #:	H00002908-M01UV (View supplier product page)
	Size	100 Tests
	Price	$419.00
	Antigen	Glucocorticoid Receptor
	Clone	2C8
	Host	Mouse
	Isotype	IgG2a κ
	Conjugate	DyLight 350
	Target Species	Human
	Applications	WB, IF, ICC
	Description	IgG purified - -

	Glucocorticoid Receptor	This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
	DyLight 350	DyLight™ 350 has an excitation peak of 353 nm and an emission peak of 432 nm. It is spectrally similar to Alexa Fluor™ 350, iFluor® 350, AMCA, and Thioflavin T. DyLight™ 350 is most commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

Glucocorticoid Receptor / DyLight 350 / 2C8