Ran / DyLight 680 / ARAN1
Ran / DyLight 680 / ARAN1
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NB600-1082FR (View supplier product page) | |
| Size | 50 Tests | |
| Price | $229.00 | |
| Antigen | Ran | |
| Clone | ARAN1 | |
| Host | Mouse | |
| Isotype | IgG2b | |
| Conjugate | DyLight 680 | |
| Target Species | Bovine, Human, Mouse | |
| Applications | WB, IP, ELISA, ICC, IF | |
| Description | IgG purified |
About Ran and DyLight 680
| Ran | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| DyLight 680 | DyLight™ 680 has an excitation peak at 692 nm and an emission peak at 712 nm, and is spectrally similar to Alexa Fluor™ 680 and Cy5.5. DyLight™ 680 is most commonly used in flow cytometery and fluorescence microscopy applications. |
Citations
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