IL-1 beta / DyLight 405LS / JK1B-1
IL-1 beta / DyLight 405LS / JK1B-1
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | NB100-78216V3 (View supplier product page) | |
| Size | 500 Tests | |
| Price | $659.00 | |
| Antigen | IL-1 beta | |
| Clone | JK1B-1 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | DyLight 405LS | |
| Target Species | Human | |
| Applications | FC, ELISA, ICC, IF | |
| Description | Protein A or G purified |
About IL-1 beta and DyLight 405LS
| IL-1 beta | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
|---|
Citations
| Additional Sources |
|
|---|
