FluoroFinder

	Supplier
	Catalog #:	NB100-148G (View supplier product page)
	Size	100 μl
	Price	$479.00
	Antigen	Rad51
	Clone	14B4
	Host	Mouse
	Isotype	IgG2b
	Conjugate	DyLight 488
	Target Species	C. elegans, Chicken, Human, Mouse
	Applications	WB, IHC-P, ICC/IF

	Rad51	The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
	DyLight 488	DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.

	Additional Sources

Rad51 / DyLight 488 / 14B4