DMTF1 / DyLight 755 / 5C6
DMTF1 / DyLight 755 / 5C6
Product Details
| Supplier | ||
|---|---|---|
| Catalog #: | H00009988-M03IR (View supplier product page) | |
| Size | 100 Tests | |
| Price | $419.00 | |
| Antigen | DMTF1 | |
| Clone | 5C6 | |
| Host | Mouse | |
| Isotype | IgG2a κ | |
| Conjugate | DyLight 755 | |
| Target Species | Human | |
| Applications | ICC, WB, IHC | |
| Description | IgG purified - - |
About DMTF1 and DyLight 755
| DMTF1 | This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | |
|---|---|---|
| DyLight 755 | DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy. |
Citations
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