FluoroFinder

	Supplier
	Catalog #:	NBP1-42210G (View supplier product page)
	Size	100 Tests
	Price	$349.00
	Antigen	MUC-1
	Clone	139H2
	Host	Mouse
	Isotype	IgG1
	Conjugate	DyLight 488
	Target Species	Human, Mouse
	Applications	FC, IHC, ELISA, IHC-Fr, IHC-P
	Description	IgG purified

	MUC-1	This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
	DyLight 488	DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.

	Additional Sources

MUC-1 / DyLight 488 / 139H2