FluoroFinder

	Supplier
	Catalog #:	H00001027-M01V (View supplier product page)
	Size	100 Tests
	Price	$419.00
	Antigen	p27 KIP 1
	Clone	4B4-E6
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	DyLight 405
	Target Species	Human
	Applications	ICC, WB, IHC, PLA
	Description	IgG purified Proximity Ligation Assay - -

	p27 KIP 1	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
	DyLight 405	DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.

	Additional Sources

p27 KIP 1 / DyLight 405 / 4B4-E6