FluoroFinder

	Supplier
	Catalog #:	H00005371-M02V2 (View supplier product page)
	Size	100 Tests
	Price	$419.00
	Antigen	PML Protein
	Clone	1D12
	Host	Mouse
	Isotype	IgG2a κ
	Conjugate	7C
	Target Species	Human, Rat
	Applications	ICC, WB, PLA
	Description	IgG purified Proximity Ligation Assay - -

	PML Protein	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
	7C	7C from Novus/ Bio-Techne is a fluorophore with an excitation peak at 423 nm and an emission peak at 499 nm. It is an alternative to V500 or AmCyan in Flow Cytometry.

	Additional Sources

PML Protein / 7C / 1D12