SLC12A1 / ATTO 565 /

Product Details
Supplier Biorbyt
Catalog #: orb152675-100ug (View supplier product page)
Size 100 μg
Price $589.00
Antigen SLC12A1
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 565
Target Species Human, Mouse, Rat
Applications WB
Description Rabbit polyclonal to NKCC2 (ATTO 565). NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide..
About SLC12A1 and ATTO 565
SLC12A1 This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
ATTO 565 ATTO 565 from ATTO-Tec Gmbh has an excitation peak at 563 nm and an emission peak at 592 nm.
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ATTO 565 Excitation and Emission Spectra