BRCA1 Polyclonal / Unconjugated /

Product Details
Supplier Abbexa
Catalog #: abx230943 (View supplier product page)
Size 100 μg
Price $434.00
Antigen BRCA1
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications ELISA, WB, IHC
Description BRCA1 Antibody is a Rabbit Polyclonal against BRCA1.
About BRCA1 and Purified
BRCA1 This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]
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Purified Excitation and Emission Spectra