Vitamin D Receptor / Unconjugated /

Product Details
Supplier Sino Biological
Catalog #: 101024-T10 (View supplier product page)
Size 100 μl
Price $149.00
Antigen Vitamin D Receptor
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications IHC-P, ICC/IF, IF
Description Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human VDR-NR111, and purified by antigen affinity chromatography.
About Vitamin D Receptor and Purified
Vitamin D Receptor This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Purified Excitation and Emission Spectra