Carbonic Anhydrase VIII / Unconjugated / 1G5G12

Product Details
Supplier Sino Biological
Catalog #: 10469-MM09 (View supplier product page)
Size 100 μl
Price $149.00
Antigen Carbonic Anhydrase VIII
Clone 1G5G12
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Target Species Human
Applications ELISA
Description This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Carbonic Anhydrase VIII / CA8 (rh Carbonic Anhydrase VIII / CA8; Catalog#10469-H08E; NP_004047.3; Met 1-Gln 290). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
About Carbonic Anhydrase VIII and Purified
Carbonic Anhydrase VIII The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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Purified Excitation and Emission Spectra