FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-30830 (View supplier product page)
	Size	0.1 ml
	Price	$519.00
	Antigen	ZP3
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human, Rat
	Applications	IHC, IHC-P, ICC/IF
	Description	Specificity of human ZP3 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

	ZP3	The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

		Immunohistochemistry-Paraffin: ZP3 Antibody [NBP2-30830] - Staining of human ovary shows strong cytoplasmic positivity in follicle cells.
		Immunohistochemistry-Paraffin: ZP3 Antibody [NBP2-30830] - Staining of human ovary shows strong cytoplasmic positivity in follicle cells.