ZAP70 Monoclonal / HRP / ZAP70/528 + 2F3.2

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-47775H (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen ZAP70
Clone ZAP70/528 + 2F3.2
Host Mouse
Isotype IgG
Conjugate HRP
Target Species Human
Applications IHC, IHC-P
Description ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
About ZAP70 and HRP
ZAP70 This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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HRP Excitation and Emission Spectra