Von Willebrand Factor Monoclonal / HRP / IIIE2.34

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-48008H (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen Von Willebrand Factor
Clone IIIE2.34
Host Mouse
Isotype IgG1 κ
Conjugate HRP
Target Species Human
Applications WB, IHC-P, IHC
Description Von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
About Von Willebrand Factor and HRP
Von Willebrand Factor This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

HRP Excitation and Emission Spectra