Vitronectin Monoclonal / DyLight 488 / HV23

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-23526G (View supplier product page)
Size 100 μl
Price $399.00
Antigen Vitronectin
Clone HV23
Host Mouse
Isotype IgG1
Conjugate DyLight 488
Target Species Bovine, Canine, Equine, Feline, Goat, Human
Applications WB, ELISA
Description Clone HV23 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). Clone HV23 cross-reacts with vitronectin from cat, dog, goat, cow and to a lesser extent with horse.
About Vitronectin and DyLight 488
Vitronectin The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra