UCHL1 Monoclonal / Unconjugated / UCHL1/775

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-48315 (View supplier product page)
Size 7 ml
Price $419.00
Antigen UCHL1
Clone UCHL1/775
Host Mouse
Isotype IgG1 κ
Conjugate Unconjugated
Target Species Human, Rat
Applications IHC-P, IHC
Description This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
About UCHL1 and Purified
UCHL1 The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
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Purified Excitation and Emission Spectra