ABCC8 Monoclonal / Alexa Fluor 405 / S289-16

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-59320AF405 (View supplier product page)
Size 100 ul
Price $549.00
Antigen ABCC8
Clone S289-16
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 405
Target Species Hamster, Human, Mouse, Rat
Applications WB, IHC, ICC/IF
Description Detects 160kDa. Does not cross-react with SUR2B.
About ABCC8 and Alexa Fluor 405
ABCC8 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra