Spastin Monoclonal / Janelia Fluor 646 / Sp 3G11/1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-50302JF646 (View supplier product page)
Size 100 μl
Price $379.00
Antigen Spastin
Clone Sp 3G11/1
Host Mouse
Isotype IgG2a
Conjugate Janelia Fluor 646
Target Species Human, Mouse, Rat
Applications IHC, ICC/IF
Description Mouse Spastin antibody [Janelia Fluor 646] reacts with Human, Mouse, Rat
About Spastin and Janelia Fluor 646
Spastin This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The use of alternative translational initiation sites in this gene results in a single transcript variant that can produce isoforms that differ in the length of their N-terminus and which thereby differ in the efficiency of their export from the nucleus to the cytoplasm. In addition, alternative splicing results in multiple transcript variants that encode isoforms that differ in other protein regions as well. One isoform of this gene has been shown to be a microtubule-severing enzyme that regulates microtubule abundance, mobility, and plus-end distribution. Mutations in this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, May 2018]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra