SHANK3 Monoclonal / Unconjugated / S367-51

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-42189-0.025mg (View supplier product page)
Size 0.025 mg
Price $199.00
Antigen SHANK3
Clone S367-51
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Target Species Human, Mouse, Rat
Applications WB, IHC, ICC/IF
Description Approx 70% identity with SHANK1 and SHANK2.Detects approx 190kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2.
About SHANK3 and Purified
SHANK3 This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
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Purified Excitation and Emission Spectra