PCNA Monoclonal / Janelia Fluor 549 / PCNA/694

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-47835JF549 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen PCNA
Clone PCNA/694
Host Mouse
Isotype IgG2a κ
Conjugate Janelia Fluor 549
Target Species Human
Applications FC, IHC, IHC-P, IF
Description Recognizes a non-histone protein of 36kDa, which is identified as proliferating cell nuclear antigen (PCNA). It is also known as cyclin or polymerase delta auxiliary protein. Elevated expression of PCNA/cyclin has been shown in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. This MAb is excellent for multiple applications.
About PCNA and Janelia Fluor 549
PCNA The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Janelia Fluor 549 Excitation and Emission Spectra