Pax7 Monoclonal / HRP / PAX7/1187

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-47922H (View supplier product page)
Size 0.1 ml
Price $539.00
Antigen Pax7
Clone PAX7/1187
Host Mouse
Isotype IgG1 κ
Conjugate HRP
Target Species Human
Applications IHC-P, IHC
Description The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).
About Pax7 and HRP
Pax7 This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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HRP Excitation and Emission Spectra