FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-49341 (View supplier product page)
	Size	0.1 ml
	Price	$519.00
	Antigen	NXF1
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	IHC, ICC/IF, IHC-P
	Description	Specificity of human NXF1 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

	NXF1	This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

		Immunocytochemistry/Immunofluorescence: NXF1 Antibody [NBP2-49341] - Staining of human cell line MCF7 shows localization to nucleoplasm. Antibody staining is shown in green.
		Immunohistochemistry-Paraffin: NXF1 Antibody [NBP2-49341] - Staining of human rectum shows strong nuclear positivity in glandular cells.